Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0042580
Disease: Vesico-Ureteral Reflux
Vesico-Ureteral Reflux 		0.100 Biomarker disease HPO
CUI: C0266383
Disease: Uterine Anomalies
Uterine Anomalies 		0.100 Biomarker group HPO
CUI: C0231679
Disease: Ulnar deviation of the fingers
Ulnar deviation of the fingers 		0.100 Biomarker phenotype HPO
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.010 PosttranslationalModification phenotype BEFREE Aberrant methylation of DACT1 and DACT2 are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma. 28077137 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 PosttranslationalModification phenotype BEFREE DACT1 methylation was significantly associated with tumor metastasis (P < 0.05), invasion (P < 0.05) and advanced tumor stage (P < 0.0005). 23073659 2012
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 AlteredExpression phenotype BEFREE High expression of DACT1 may inhibit the invasion and metastasis of nasopharyngeal carcinoma cells. 31182157 2019
CUI: C0241397
Disease: Triphalangeal thumb
Triphalangeal thumb 		0.100 Biomarker disease HPO
CUI: C4479534
Disease: TOWNES-BROCKS SYNDROME 2
TOWNES-BROCKS SYNDROME 2 		0.300 Biomarker disease GENOMICS_ENGLAND Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. 19701191 2009
CUI: C4479534
Disease: TOWNES-BROCKS SYNDROME 2
TOWNES-BROCKS SYNDROME 2 		0.300 Biomarker disease GENOMICS_ENGLAND Heterozygous Pathogenic Variant in DACT1 Causes an Autosomal-Dominant Syndrome with Features Overlapping Townes-Brocks Syndrome. 28054444 2017
CUI: C4479534
Disease: TOWNES-BROCKS SYNDROME 2
TOWNES-BROCKS SYNDROME 2 		0.300 Biomarker disease GENOMICS_ENGLAND Identification of novel rare mutations of DACT1 in human neural tube defects. 22610794 2012
CUI: C0265246
Disease: Townes syndrome
Townes syndrome 		0.510 Biomarker disease CTD_human
CUI: C0265246
Disease: Townes syndrome
Townes syndrome 		0.510 GermlineCausalMutation disease ORPHANET Together, these findings suggest that the DACT1 c.1256G>A nonsense variant is causative of a specific genetic syndrome with features overlapping Townes-Brocks syndrome. 28054444 2017
CUI: C0265246
Disease: Townes syndrome
Townes syndrome 		0.510 GeneticVariation disease BEFREE Together, these findings suggest that the DACT1 c.1256G>A nonsense variant is causative of a specific genetic syndrome with features overlapping Townes-Brocks syndrome. 28054444 2017
CUI: C0039685
Disease: Tetralogy of Fallot
Tetralogy of Fallot 		0.100 Biomarker disease HPO
CUI: C0265660
Disease: Syndactyly of the toes
Syndactyly of the toes 		0.100 Biomarker disease HPO
CUI: C0151811
Disease: Subcutaneous nodule
Subcutaneous nodule 		0.100 Biomarker phenotype HPO
CUI: C0038379
Disease: Strabismus
Strabismus 		0.100 Biomarker disease HPO
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.010 PosttranslationalModification group BEFREE Moreover, promoter methylation of DACT1 was detected in 29.3% (60/205) of primary gastric tumors. 23073659 2012
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.030 Biomarker disease BEFREE Cyclin G2 suppresses Wnt/β-catenin signaling and inhibits gastric cancer cell growth and migration through Dapper1. 30547803 2018
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.030 Biomarker disease BEFREE Dapper homolog 1 alpha suppresses metastasis ability of gastric cancer through inhibiting planar cell polarity pathway. 27833078 2016
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.030 Biomarker disease BEFREE Dapper homolog 1 is a novel tumor suppressor in gastric cancer through inhibiting the nuclear factor-κB signaling pathway. 23073659 2012
CUI: C2931507
Disease: Sternal cleft
Sternal cleft 		0.100 Biomarker disease HPO
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.010 AlteredExpression disease BEFREE The TSS region hypermethylation may be one of the main mechanisms for reduced expression of DACT1 and DACT2 in ESCC. 28077137 2017
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.010 AlteredExpression disease BEFREE Expression and epigenetic regulation of DACT1 and DACT2 in oral squamous cell carcinoma. 25524937 2015
CUI: C0266501
Disease: Spina bifida of cervical region
Spina bifida of cervical region 		0.100 Biomarker disease HPO